| Transzgén/Vonal | Jax azonosító | Pubmed azonosító | Kontakt személy | Vonal eredeti tulajdonosa |
| FVB/Ant | https://www.jax.org/strain/004828 | http://www.ncbi.nlm.nih.gov/pubmed/17083330 | Erdélyi Ferenc | |
This strain originated on a FVB;129P2 background, and was
backcrossed for 11 generations on the FVB background. |
|
| BAC_pva/gfp 2 | | 12177202 | Szabó Gábor | Hannah Monyer* |
Pva-gfp transgenic mice express gfp in parvalbumin-expressing
neurons and muscle.
* BAC construct was designed by AH Meyer in Monyer's lab.
Pronuclear microinjection was carried out in IEM-HAS. |
|
| calb1/folA-egfp-cre Tm | 023531 | | Hájos Norbert | |
| cre is expressed in neurons expressing calbindin |
|
| camK2A/gfp 22 | | | Szabó Gábor | Szabó Gábor |
CamK2A-gfp transgenic mice express gfp in piramidal and
purkinje cells.
Construct and microinjection were carried out in IEM-HAS. |
|
| cck/ires-cre Tm | 012706 | | Hájos Norbert | |
cre is expressed in both glutamatergic and GABAergic neurons
containing CCK |
|
| crh/ires-cre Tm | 012704 | 21943598 | Tóth Máté | Z. Josh Huang, Cold Spring Harbor Laboratory |
| |
|
| Cx3cr1/cre Tg | 020940 | | Dénes Ádám | Steffen Jung |
| |
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| D2 (f) Tm | - | 23524969 | Gereben Balázs | AC Bianco, Miami FL, Gereben B. |
| floxolt kettes-típusú dejodáz enzim |
|
| D3 (f) Tm | - | - | Gereben Balázs | D. Salvatore, Nápoly |
| floxolt hármas-típusú dejodáz enzim |
|
| DAT/IRES-cre Tm | | | Hangya Balázs | |
| |
|
| dlx5/6/flpe Tg | 010815 | | Hájos Norbert | |
| dlx5/6-flpe may be used in intersect strategy. |
|
| fos/cre-ERT2 Tm | 021882 | | Hájos Norbert | |
cre is expressed under the control of fos in a tamoxifen-
dependent manner. |
|
| gad65_3e/gfp 5.5 30 | | 15115742 | Szabó Gábor | Szabó Gábor |
| gad65-gfp transgenic mice express gfp in interneurons under the control of gad2 promoter and 5.3 kb length upstream region. |
|
| Gjd2 (cnx36) Tm Fl | | | Gergely Szarka | |
| Gjd2 cKO |
|
| gluRa2 (f) Tm | | 17296559 | Hájos Norbert | Hannah Monyer |
| floxed-GluR1 mouse strain, Fuchs et al., 2007 Neuron |
|
| gluRd2 (f) Tm | | 17296559 | Hájos Norbert | Hannah Monyer |
| floxed-GluR4 mouse strain, Fuchs et al., 2007 |
|
| GT(ROSA)26Sor_CAG_LSL/gcamp6s Tm | 24275 | PMID: 23868258 | Dénes Ádám | |
| |
|
| GT(ROSA)26Sor_CAG/LSL_CHRM3_mCitrine Tm | 026220 | | Dénes Ádám | Dr. Ute Hochgeschwender, Bryan L Roth |
| |
|
| Gt(ROSA)26Sor_CAG/LSL_GFP-OMM Tm | 032675 | | | Dénes Ádám |
MitoTag (Rosa26-CAG-LSL-GFP-OMM) is a Gt(ROSA)26Sor knock-in
allele that has a loxP-flanked STOP cassette preventing
transcription of an outer mitochondrial membrane-targeted
enhanced green fluorescent protein (GFP-OMM). These mice are
designed to allow Cre recombinase-inducible EGFP fluorescence
that faithfully localizes to mitochondria (with no observed
cytosolic fluorescence). |
|
| Gt(ROSA)26Sor_CAG/LSL_tdTomato Ai9 | 007905 | 20023653 | Erdélyi Ferenc | Hongkui Zeng, Allen Institute for Brain Science (AIBS) |
| These Ai9 mice harbor a targeted mutation of the Gt(ROSA)26Sor locus with a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven red fluorescent protein variant (tdTomato), and may be useful as a Cre reporter strain. TdTomato is expressed following Cre-mediated recombination. |
|
| Gt(ROSA)26Sor_CAG/LSL_ZsGreen1 Tm | 007906 | 20023653 | Erdélyi Ferenc | Hongkui Zeng, Allen Institute for Brain Science (AIBS) |
| These Ai6 mice harbor a targeted mutation of the Gt(ROSA)26Sor locus with a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven enhanced green fluorescent protein (ZsGreen1), and may be useful as a Cre reporter strain. ZsGreen1 is expressed following Cre-mediated recombination. |
|
| Gt(ROSA)26Sor/CAG/GCaMP3 Tm | 014538 | 22378886 | Erdélyi Ferenc | Hongkui Zeng, Allen Institute for Brain Science (AIBS) |
| Ai38 mice express the fluorescent calcium indicator protein GCaMP3 after exposure to Cre recombinase. Following subsequent calcium binding (such as neuronal activation), bright EGFP fluorescence is observed. |
|
| GT(ROSA)26Sor/Cre - | | 18799753 | Erdélyi Ferenc | |
| The Cre Deleter mouse was developed by Artemis Pharmaceuticals (now Taconic). The mutant was created by a targeted mutation knock-in of Cre into the Gt(ROSA)26 locus. Cre is expressed under the control of the Gt(ROSA)26Sor gene. |
|
| Hexb/creERT2 Tg | | PMID: 32541832 | Dénes Ádám | Marco Prinz, University of Freiburg, Medical Faculty |
| |
|
| Hexb/tdTomato Tg | | PMID: 32541832 | Dénes Ádám | Marco Prinz, University of Freiburg, Medical Faculty |
| |
|
| IL-1αß(-) TmTm | | PMID: 9565638 | Dénes Ádám | Stuart M. Allan, Emmanuel Pinteaux |
| |
|
| IL-1R1(f) Tm | | 26692072 | Dénes Ádám | Ari Waisman, Werner Müller |
| |
|
| IL-1α (f)//IL-1ß (f) TmTm | | | Dénes Ádám | Stuart M. Allan, Emmanuel Pinteaux |
| |
|
| IL1R1 (-) Tm | | PMID: 26692072 | Dénes Ádám | Emmanuel Pinteaux, Stuart M Allan, Ari Waisman, Werner Müller |
| |
|
| IL6 (Em) 1 | | | Kovács Krisztina | Kovács Krisztina |
Az egeret CRIPR/Cas9 technikával állította elő a KOKI Orvosi
Géntechnológiai Részlege, Erdélyi Ferenc, Máté Zoltán és Dr.
Szabó Gábor. A gén kiütése STOP kodon beépítésével történt a 4.
splice variáns első exonjába. Background: FVB/Ant. -/- és +/+
vonalakat tenyésztünk. Az LPS-sel kezelt KO állatok plazmájában
ELISA-val nem mérhető IL-6. |
|
| lysM/cre//IL-1R1(f) TgTm | 004781 | | Dénes Ádám | Irmgard Foerster |
| |
|
| Lyve1/Ncre//Cx3cr1/Ccre EmEm | 033319 | 33333014 | Dénes Ádám | Steffen Jung - Weizmann Institute of Science |
| |
|
| nestin/cre_ERT2 Tg | | 18160632 | Fekete Csaba | G Fishell, New York, NY |
| Tamoxifen-indukálható Cre rekombináz nestin promóter alatt |
|
| nestin/cre_ERT2//IL-1R1(f) TmTm | 012906 | | Dénes Ádám | Chia-Yi Kuan |
| |
|
| nkcc1 (f) Tm | | | Dénes Ádám | Kai Kaila |
| |
|
| pf4/icre Tg | 008535 | 17032923 | Dénes Ádám | Radek Skoda |
| |
|
| pf4/icre//IL-1R1(f) TgTm | 008535 | | Dénes Ádám | Radek Skoda |
| |
|
| Polr2a_pb_CAG/LSL_GCaMP5g-tdTomato Tm | 024477 | PMID: 25155958 | Dénes Ádám | Petr Tvrdik, University of Utah |
| |
|
| PSEN1//App_swe//tauP301L TmTgTg | 34830-JAX | | Hangya Balázs | |
B6;129-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/Mmjax
3xTg-AD |
|
| pva/IRES_cre - | 017320 | 17190606 | Szabó Gábor | Silvia Arber |
| PV-Cre knockin mice express Cre recombinase in parvalbumin-expressing neurons (such as interneurons in the brain and proprioceptive afferent sensory neurons in the dorsal root ganglia), without disrupting endogenous Pvalb expression. |
|
| rax/cre-ert2 Tg | | | Fekete Csaba | Seth Blackshaw |
| Az állat a Rax promoter alatt tamoxifen indukálható Cre-t termel. Felnõtt állatban az expresszió tanicita specifikus. |
|
| Sall1/Ncre//Cx3cr1/Ccre EmEm | 033318 | | | Dénes Ádám |
These CRISPR/Cas9 generated Sall1ncre:Cx3cr1ccre (CX/Sall1) mice
use a binary transgenic cre approach to dissect functions of
central nervous system (CNS) macrophage subpopulations. |
|
| sb/CAG/yfp/sb 27 | | | Erdélyi Ferenc | Szabó Gábor |
| Sleeping Beauty-CAG-Venus construct was made by Lajos Mátes (BRC). Transgene is integrated in one copy. Fluorescent protein expression can be found in endothelial cells and in Purkinje cells in brain. |
|
| Scl/CreERT Tg | 037467 | 15187022 | Dénes Ádám | Joachim Goethert |
| |
|
| Scl/CreERT//IL-1R1(f) TgTm | | PMID: 15187022 | Dénes Ádám | |
| |
|
| Slco1c1/iCreERT2//IL-1R1(f) TgTm | | | Dénes Ádám | Markus Schwaninger |
| |
|
| Tau/LSL/mgfp_iresNlacZ Tm | B6;129P2-Mapttm2Arbr/J | 15836427 | Fekete Csaba | Silvia Arber |
Description
In these TaumGFP mice, Cre recombinase activity induces expression of membrane bound green fluorescent protein (mGFP) and nuclear targeted beta-galactosidase in neurons. mGFP, MARCKS ("myristoylated alanine-rich C-kinase substrate") protein fused to green fluorescent protein, targets GFP expression to the membrane, and IRES-NLS-lacZ targets expression of beta-galactosidase to the nucleus. A floxed STOP cassette prevents expression of the reporter genes until removed by Cre recombinase activity. The construct replaces the endogenous start codon in exon 2. Homozygotes are viable and fertile.
Development
A targeting vector designed by Drs. Silvia Arber and Markus Sigrist (Biozentrum, University of Basel) containing floxed STOP sequence, membrane-targeted green fluorescent protein, nuclear targeted beta-galactosidase and polyadenylation signal sequence (loxP-STOP-loxP-mGFP-IRES-NLS-lacZ-pA) was inserted into exon 2. The construct was electroporated into 129P2/OlaHsd derived E14 embryonic stem (ES) cells. Correctly targeted ES cells were injected into blastocysts. The resulting chimeric animals were tested for germline transmission. The mice were crossed to C57BL/6JRccHsd mice. Upon arrival at The Jackson Laboratory, the mice were crossed to C57BL/6J (Stock No. 000664) at least once to establish the colony. |
|
| Thy1/cre Tg | Thy1/cre (Tg) | | | Rózsa Balázs |
| |
|
| Thy1/gcamp6s Tg | 024275 | PMID: 23868258 | Dénes Ádám | Douglas Kim, Janelia Farm Research Campus, HHMI |
| |
|
| vglut1/cre Tm | 023527 | | Hájos Norbert | |
cre is expressed spacifically in forebrain glutamatergic
neurons |
|
